"For whosoever will save his life shall lose it: and whosoever will lose his life for my sake shall find it. For what is a man profited, if he shall gain the whole world, and lose his own soul? or what shall a man give in exchange for his soul?" (Matthew 16:25-26)
Assuming you believe in a "soul". I mean, if you don't have a soul, nothin' to worry about right? But what if you did? What if you could introspectively place a higher value on yourself (as it would be something you wouldn't be able to touch--at least not directly) than just a measure of earth reconstituted as your body? What if you were more than your body? What would you do then?
Second opinions
"And Satan answered the Lord, and said, Skin for skin, yea, all that a man hath will he give for his life." (Job 2:4)
I don't know if that's entirely true. Best not to take anything the devil says--even though it might have a patina of accuracy or authenticity--as truth. There are people who are adamant, even on their deathbed, against God. And I feel the belief in a soul lends itself to openness to His existence. Best not to wait till then to make up your mind.
"None of them can by any means redeem his brother, nor give to God a ransom for him: (For the redemption of their soul is precious, and it ceaseth for ever:) That he should still live for ever, and not see corruption." (Psalm 49:7-9)
What do we talk about when we talk about a soul? As we all have one (I'm jumping ahead here, forgive me) but few have seen theirs, does this qualify us to opine intelligently on the matter? Just because you have a body, doesn't mean you know why it's doing what it does--not until you learn, anyway. And there are some doctors who are better than others. One would tell you to do one thing to solve a physical ailment while another would advise against it. You can treat yourself as a test subject, but only up to a certain point. And regarding the soul, does any veracity you ascribe to the Bible and what it says hold weight in the mundane matters of life? God knows. And if I take from one source, wouldn't this mean that anytime someone talks about my "soul", they're coming at it from the same perspective as I? Not if they don't acknowledge the same God, I'm sorry to say. Paul writes this to the Thessalonians:
"And the very God of peace sanctify you wholly; and I pray God your whole spirit and soul and body be preserved blameless unto the coming of our Lord Jesus Christ." (1 Thessalonians 5:23)
Breaking the skin
See! See right there. Distinguishing between the two, Paul effectively lifts this question one higher. The writer of Hebrews (I think it was Paul) refers to the word of God. "Quick (alive), and powerful, and sharper than any twoedged sword, piercing even to the dividing asunder of soul and spirit, and of the joints and marrow, and is a discerner of the thoughts and intents of the heart." (Hebrews 4:12)
God has things to say on the matter. I could cite them all here but I'm not going to. I will say this though: practice a little counterintuition. Try on Jesus and see if what He says how if you forget about yourself and focus on Him, that you would, maybe, get to see your own soul. It's like giving up your own life in order to get it from Him (I'm just paraphrasing what He said). It works once and for always.